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Search content: Tumor = All Tumor Types

There are 338 entries with your keyword(s).

Gene	Variant	Type	Tumor	Drug	Drug level	Reference

ABL1	ABL1-BCR	FUS	All Tumor Types	Bafetinib	RIII	1
About trial About gene About drug Evidence region CIVIC Patient Criteria F317L Note In an in vitro study, a Ba/F3 cell line stably expressing the F317L mutation in the ABL1 portion of the BCR-ABL1 fusion protein was associated with similar sensitivity to nilotinib and bafetinib treatment (IC50: 929.8 nM and 293.5 nM) as compared to wild-type BCR-ABL1 expressing Ba/F3 cells (IC50: 642.3 nM and 152.9 nM). Sensitivity was determined by assessing cell proliferation using the MTT assay. Gene name ABL1 Full name ABL proto-oncogene 1, non-receptor tyrosine kinase Gene type protein-coding Function This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] Drug name Bafetinib DrugBank ID DB11851 Synonyms Bafétinib Bafetinib Bafetinibum Brand - Description Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others. Target gene -
ABL1	ABL1-BCR	FUS	All Tumor Types	Bafetinib	RIII	1
About trial About gene About drug Evidence region CIVIC Patient Criteria F317V Note In an in vitro study, a Ba/F3 cell line stably expressing the dasatinib-resistance variant F317V in the ABL1 portion of the BCR-ABL1 fusion protein was associated with similar sensitivity to imatinib, nilotinib and bafetinib (INNO-406) treatment (IC50: 1053.7, 286.9 nM, 284 nM) as compared to wild-type BCR-ABL1 expressing Ba/F3 cells (IC50: 1712 nM, 642.3 nM, and 152.9 nM). Sensitivity was determined by assessing cell proliferation using the MTT assay. Gene name ABL1 Full name ABL proto-oncogene 1, non-receptor tyrosine kinase Gene type protein-coding Function This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] Drug name Bafetinib DrugBank ID DB11851 Synonyms Bafétinib Bafetinib Bafetinibum Brand - Description Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others. Target gene -
ABL1	ABL1-BCR	FUS	All Tumor Types	Bafetinib	RIII	1
About trial About gene About drug Evidence region CIVIC Patient Criteria G250E Note In an in vitro study, a Ba/F3 cell line stably expressing the G250E mutation in the ABL1 portion of the BCR-ABL1 fusion protein was associated with resistance to imatinib and bafetinib (INNO-406) treatment (IC50: > 2000.0 nM and 852 nM) as compared to wild-type BCR-ABL1 expressing Ba/F3 cells (IC50: 1712 nM and 152.9 nM). Sensitivity was determined by assessing cell proliferation using the MTT assay. Gene name ABL1 Full name ABL proto-oncogene 1, non-receptor tyrosine kinase Gene type protein-coding Function This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] Drug name Bafetinib DrugBank ID DB11851 Synonyms Bafétinib Bafetinib Bafetinibum Brand - Description Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others. Target gene -
ABL1	ABL1-BCR	FUS	All Tumor Types	Bafetinib	RIII	1
About trial About gene About drug Evidence region CIVIC Patient Criteria H396P Note In an in vitro study, a Ba/F3 cell line stably expressing H396P in the ABL1 portion of the BCR-ABL1 fusion protein was associated with similar sensitivity to nilotinib and bafetinib (INNO-406) treatment (IC50: 986.9 nM and 280.1 nM) as compared to wild-type BCR-ABL1 expressing Ba/F3 cells (IC50: 642.3 nM and 152.9 nM). Sensitivity was determined by assessing cell proliferation using the MTT assay. Gene name ABL1 Full name ABL proto-oncogene 1, non-receptor tyrosine kinase Gene type protein-coding Function This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] Drug name Bafetinib DrugBank ID DB11851 Synonyms Bafétinib Bafetinib Bafetinibum Brand - Description Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others. Target gene -
ABL1	ABL1-BCR	FUS	All Tumor Types	Bafetinib	RIII	1
About trial About gene About drug Evidence region CIVIC Patient Criteria M244V Note In an in vitro study, a Ba/F3 cell line stably expressing the M244V mutation in the ABL1 portion of the BCR-ABL1 fusion protein was associated with resistance to imatinib and bafetinib (INNO-406) treatment (IC50: > 2000.0 nM and 874.2 nM) as compared to wild-type BCR-ABL1 expressing Ba/F3 cells (IC50: 1712 nM and 152.9 nM). Sensitivity was determined by assessing cell proliferation using the MTT assay. Gene name ABL1 Full name ABL proto-oncogene 1, non-receptor tyrosine kinase Gene type protein-coding Function This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] Drug name Bafetinib DrugBank ID DB11851 Synonyms Bafétinib Bafetinib Bafetinibum Brand - Description Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others. Target gene -
ABL1	ABL1-BCR	FUS	All Tumor Types	Bafetinib	RIII	1
About trial About gene About drug Evidence region CIVIC Patient Criteria M351T Note In an in vitro study, a Ba/F3 cell line stably expressing the M351T mutation in the ABL1 portion of the BCR-ABL1 fusion protein was associated with similar sensitivity to nilotinib, dasatinib, and bafetinib treatment (IC50: 580.4 nM, 88 nM, 582.9 nM) as compared to wild-type BCR-ABL1 expressing Ba/F3 cells (IC50: 642.3 nM, 87.6 nM, 152.9 nM). Sensitivity was determined by assessing cell proliferation using the MTT assay. Gene name ABL1 Full name ABL proto-oncogene 1, non-receptor tyrosine kinase Gene type protein-coding Function This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] Drug name Bafetinib DrugBank ID DB11851 Synonyms Bafétinib Bafetinib Bafetinibum Brand - Description Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others. Target gene -
ABL1	ABL1-BCR	FUS	All Tumor Types	Bafetinib	RIII	1
About trial About gene About drug Evidence region CIVIC Patient Criteria Q252H Note In an in vitro study, a Ba/F3 cell line stably expressing the Q252H mutation in the ABL1 portion of the BCR-ABL1 fusion protein was associated with resistance to imatinib and bafetinib (INNO-406) treatment (IC50: > 2000.0 nM and 888.1 nM) as compared to wild-type BCR-ABL1 expressing Ba/F3 cells (IC50: 1712 nM and 152.9 nM). Sensitivity was determined by assessing cell proliferation using the MTT assay. Gene name ABL1 Full name ABL proto-oncogene 1, non-receptor tyrosine kinase Gene type protein-coding Function This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] Drug name Bafetinib DrugBank ID DB11851 Synonyms Bafétinib Bafetinib Bafetinibum Brand - Description Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others. Target gene -
ABL1	ABL1-BCR	FUS	All Tumor Types	Bafetinib	RIII	1
About trial About gene About drug Evidence region CIVIC Patient Criteria T315A Note In an in vitro study, a Ba/F3 cell line stably expressing the dasatinib-resistance variant T315A in the ABL1 portion of the BCR-ABL1 fusion protein was associated with similar sensitivity to nilotinib and bafetinib (INNO-406) treatment (IC50: 949.2 nM, 422.5 nM) as compared to wild-type BCR-ABL1 expressing Ba/F3 cells (IC50: 642.3 nM and 152.9 nM). Sensitivity was determined by assessing cell proliferation using the MTT assay. Gene name ABL1 Full name ABL proto-oncogene 1, non-receptor tyrosine kinase Gene type protein-coding Function This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] Drug name Bafetinib DrugBank ID DB11851 Synonyms Bafétinib Bafetinib Bafetinibum Brand - Description Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others. Target gene -
ABL1	ABL1-BCR	FUS	All Tumor Types	Bafetinib	RIII	1
About trial About gene About drug Evidence region CIVIC Patient Criteria T315I Note In an in vitro study, a Ba/F3 cell line stably expressing the T315I mutation in the ABL1 portion of the BCR-ABL1 fusion protein was associated with resistance to nilotinib, imatinib, dasatinib, and bafetinib (INNO-406) treatment (IC50: > 2000.0 nM) as compared to wild-type BCR-ABL1 expressing Ba/F3 cells (IC50: 642.3 nM, 1712 nM, 87.6 nM and 152.9 nM). Sensitivity was determined by assessing cell proliferation using the MTT assay. Gene name ABL1 Full name ABL proto-oncogene 1, non-receptor tyrosine kinase Gene type protein-coding Function This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] Drug name Bafetinib DrugBank ID DB11851 Synonyms Bafétinib Bafetinib Bafetinibum Brand - Description Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others. Target gene -
ABL1	ABL1-BCR	FUS	All Tumor Types	Bafetinib	RIII	1
About trial About gene About drug Evidence region CIVIC Patient Criteria Y253F Note In an in vitro study, a Ba/F3 cell line stably expressing the Y253F mutation in the ABL1 portion of the BCR-ABL1 fusion protein was associated with similar sensitivity to nilotinib, dasatinib, and bafetinib (INNO-406) treatment (IC50: 975.3 nM, 16.8 nM, and 490.8 nM) as compared to wild-type BCR-ABL1 expressing Ba/F3 cells (IC50: 642.3 nM, 87.6 nM, and 152.9 nM). Sensitivity was determined by assessing cell proliferation using the MTT assay. Gene name ABL1 Full name ABL proto-oncogene 1, non-receptor tyrosine kinase Gene type protein-coding Function This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] Drug name Bafetinib DrugBank ID DB11851 Synonyms Bafétinib Bafetinib Bafetinibum Brand - Description Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others. Target gene -

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